Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM. |
Targets&IC50 | CYP3A4:13 μM (EC50), MCHR1 (rat):7 nM (ki) |
In vitro | BMS-819881 (Compound 27) is 99.8% binds to rat serum proteins and rat MCHR1 Ki is 7 nM. When BMS-819881 is screened for cytochrome P450 (CYP) activity, EC50 values for CYP1A2, CYP2C9, CYP2C19, CYP2D6 are >40 μM; however, the CYP3A4 EC50 is 13 μM. The percent of BMS-819881 binds to serum proteins is species dependent ranging from 99.8%, 99.6%, and 99.3%, respectively, for rat, dog, and monkey. FLIPR-based assays establish that BMS-819881 is a potent and highly selective MCHR1 functional antagonist. BMS-819881 (Kb=32 nM) effectively blocks MCH stimulated Ca2+ mobilization in heterologous cells overexpressing MCHR1 but fails to inhibit MCH mediated Ca2+ mobilization of cells expressing MCHR2 at 10 μM. No activity is observed upon screening BMS-819881 at 10 μM versus a panel of 20 GPCRs associated with feeding homeostasis [1]. |
In vivo | BMS-819881 exhibits a moderate terminal elimination half-life, with values recorded at 5.7 hours for rats, 32±8 hours for dogs, and 14±3 hours for cynomolgus monkeys, all administered at a dosage of 1 mg/kg intravenously[1]. |
Molecular Weight | 468.95 |
Formula | C24H21ClN2O4S |
CAS No. | 1197420-05-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BMS-819881 1197420-05-5 Metabolism P450 BMS 819881 BMS819881 inhibitor inhibit