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BMS 180448

Catalog No. T30487 CAS 144264-47-1

Synonyms: BMS-180448, BMS180448

BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.

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BMS 180448, CAS 144264-47-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.

Synonyms	BMS-180448, BMS180448
Molecular Weight	395.84
Formula	C20H18ClN5O2
CAS No.	144264-47-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lee JH, Jung IS, Lee SH, Yang MK, Hwang JH, Lee HD, Cho YS, Song MJ, Yi KY, Yoo SE, Kwon SH, Kim B, Lee CS, Shin HS. Cardioprotective effects of BMS-180448, a prototype mitoK(ATP) channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injury. Arch Pharm Res. 2007 May;30(5):634-40. PubMed PMID: 17615684. 2. Park YS, Yoo SE, Shin HS, Jin YR, Yun YP. Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta. J Pharmacol Sci. 2003 Jul;92(3):218-27. PubMed PMID: 12890887. 3. Weselcouch EO, Gomoll AW. Selectivity of BMS-180448 on myocardial versus brain blood flow in dogs and ferrets. J Cardiovasc Pharmacol. 1997 Jul;30(1):61-8. PubMed PMID: 9268222. 4. Gomoll AW, Roth RA, Swillo RE, Baird AJ, Sargent CS, Behling RW, Malone HJ, Grover GJ. Effect of timing of treatment of the glyburide-reversible cardioprotective activity of BMS-180448. J Pharmacol Exp Ther. 1997 Apr;281(1):24-33. PubMed PMID: 9103476.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS 180448 144264-47-1 BMS-180448 BMS180448 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.