Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 76.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 263.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator. |
In vitro | BC-1258, stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice.?These findings uncover a new proteolytic mechanism targeting a key regulator of cell replication that may serve as a basis for chemotherapeutic intervention in neoplasia. |
Synonyms | BC-1258 |
Molecular Weight | 406.57 |
Formula | C22H22N4S2 |
CAS No. | 1507370-40-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.07 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BC-1258 1507370-40-2 Apoptosis LRR F-box BC1258 inhibit repeat BC-1258 BC-?1258 BC 1258 FBXL2 tumor Inhibitor BC1258 BC 1258 inhibitor