store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of <1000, without obvious harm to lung epithelial cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 1,530.00 | |
1 mL * 10 mM (in DMSO) | In stock | Inquiry |
Description | Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. |
In vitro | We set out to determine whether Artocarpin has cytotoxic effects on SCC cells and whether its pharmacological activity is dependent on protein-nutrient concentration. Our results showed that treatment of HSC-1 cells (a human cutaneous SCC cell line) with Artocarpin decreased cell viability and induced cell apoptosis by increasing caspase 3/7 activity. These effects were more pronounced at low fetal bovine serum (FBS) concentrations. Artocarpin induced an increase in the level of phospho-p38 and a decrease in the levels of phospho-ERK, phospho-JNK, phospho-Akt, phospho-mTOR, and phospho-S6K. High FBS concentrations in the culture media inhibited and delayed the uptake of Artocarpin from the extracellular compartment (culture media) into the intracellular compartment, as determined by high performance liquid chromatography (HPLC) analysis[1] |
Source |
Molecular Weight | 436.5 |
Formula | C26H28O6 |
CAS No. | 7608-44-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Artocarpin 7608-44-8 Apoptosis Immunology/Inflammation Neuroscience IL Receptor TNF COX inhibitor inhibit