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Arbidol

Catalog No. T7911 CAS 131707-25-0

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir both suppresses virus propagation and modulates the expression of inflammatory cytokines and is used as an anti-influenza virus agent [3]. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2].

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Arbidol, CAS 131707-25-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir both suppresses virus propagation and modulates the expression of inflammatory cytokines and is used as an anti-influenza virus agent [3]. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2].
In vitro	Umifenovir exhibits broad and potent antiviral effects, demonstrating efficacy against an array of viruses such as influenza types A, B, and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV, and HCV [1].
In vivo	Umifenovir, administered orally at doses of 25 and 45 mg/kg/day, demonstrated a survival advantage in BALB/c mice aged 6–8 weeks, inflicted with influenza. The mice were exposed intranasally to a dose twice the 50% lethal dose for mice (2xMLD50) of the A/Guangdong/GIRD07/09 (H1N1) strain, amounting to 10^4.5 TCID50/mL in a 20mL volume. The treatment commenced one day before infection and continued for three days post-infection. Results indicated that at a concentration of 45 mg/mL, Umifenovir significantly increased survival rates and halted the reduction of body weight observed in the virus group. Additionally, at doses of 25 mg/mL and 45 mg/mL, it effectively prevented the escalation of the lung index in mice, thereby showing its potency in mitigating the severity of influenza infections.

Molecular Weight	477.41
Formula	C22H25BrN2O3S
CAS No.	131707-25-0

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Arbidol 131707-25-0 inhibitor inhibit

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