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Aprikalim

Catalog No. T25102 CAS 132562-26-6

Synonyms: RP52891, RP-52891, RP 52891

Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.

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Aprikalim, CAS 132562-26-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.

Synonyms	RP52891, RP-52891, RP 52891
Molecular Weight	268.4
Formula	C12H16N2OS2
CAS No.	132562-26-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lozos VA, Toumpoulis IK, Agrogiannis G, Giamarellos-Bourboulis EJ, Chamogeorgakis TP, Rizos IK, Patsouris ES, Anagnostopoulos CE, Rokkas CK. Aprikalim a potassium adenosine triphosphate channel opener reduces neurologic injury in a rabbit model of spinal cord ischemia. Int J Surg. 2013;11(4):354-9. doi: 10.1016/j.ijsu.2013.02.025. Epub 2013 Mar 5. PubMed PMID: 23473993. 2. He GW, Yang CQ. Inhibition of vasoconstriction by potassium channel opener aprikalim in human conduit arteries used as bypass grafts. Br J Clin Pharmacol. 1997 Oct;44(4):353-9. PubMed PMID: 9354310; PubMed Central PMCID: PMC2042851. 3. Pignac J, Lacaille C, Dumont L. Protective effects of the K+ ATP channel opener, aprikalim, against free radicals in isolated rabbit hearts. Free Radic Biol Med. 1996;20(3):383-9. PubMed PMID: 8720909. 4. Belin V, Hodge T, Picaut P, Jordan R, Algate C, Gosselin S, Nohynek G, Cavero I. The myocardial lesions produced by the potassium channel opener aprikalim in monkeys and rats are prevented by blockade of cardiac beta-adrenoceptors. Fundam Appl Toxicol. 1996 Jun;31(2):259-67. PubMed PMID: 8789792.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aprikalim 132562-26-6 RP52891 RP-52891 RP 52891 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.