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Antofloxacin Hydrochloride

Catalog No. T26638 CAS 873888-67-6

Synonyms: (S)-Antofloxacin hydrochloride, Antofloxacin HCl

Antofloxacin Hydrochloride, a fluoroquinolone antimicrobial, is used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Antofloxacin Hydrochloride Chemical Structure

Antofloxacin Hydrochloride, CAS 873888-67-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Antofloxacin Hydrochloride, a fluoroquinolone antimicrobial, is used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis(AP), acute cystitis and multiple folliculitis.

Synonyms	(S)-Antofloxacin hydrochloride, Antofloxacin HCl
Molecular Weight	412.84
Formula	C18H22ClFN4O4
CAS No.	873888-67-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Liu L, Pan X, Liu HY, Liu XD, Yang HW, Xie L, Cheng JL, Fan HW, Xiao DW. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011 Oct;32(10):1285-93. doi: 10.1038/aps.2011.78. PubMed PMID: 21892200; PubMed Central PMCID: PMC4010077. 2. Wang J, Xiao Y, Lu Y, Kang Z, Zhang M, Liu Y, Liang J, Zhang M, Li T. Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration. Xenobiotica. 2011 Jul;41(7):561-6. doi: 10.3109/00498254.2011.565820. PubMed PMID: 21446836. 3. Lü Y, Kang ZS, Zhu Y, Zhang M, Liu Y, Zhang M, Li TY, Xiao YH. Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers. Chin Med J (Engl). 2011 Jan;124(2):242-5. PubMed PMID: 21362374. 4. Zhao J, Liu Y, Jiang X, Guo P, Xu Y, Zhang P, Ji T, Lin Z, Wang W. Effect of C-5 position on the photochemical properties and phototoxicity of antofloxacin and levofloxacin: A stable and transient study. J Photochem Photobiol B. 2016 Feb;155:122-9. doi: 10.1016/j.jphotobiol.2015.12.004. PubMed PMID: 26746788.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Antofloxacin Hydrochloride 873888-67-6 (S)-Antofloxacin hydrochloride Antofloxacin HCl inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.