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Antagonist G

Catalog No. T20481 CAS 115150-59-9

Synonyms: Arg-trp-N-methyl-phe-trp-leu-met-NH2

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.

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Antagonist G, CAS 115150-59-9

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 954.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.

Synonyms	Arg-trp-N-methyl-phe-trp-leu-met-NH2
Molecular Weight	951.19
Formula	C49H66N12O6S
CAS No.	115150-59-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. MacKinnon AC, Waters C, Rahman I, Harani N, Rintoul R, Haslett C, Sethi T. [Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct;83(7):941-8. PubMed PMID: 10970698; PubMed Central PMCID: PMC2374683. 2. Clive S, Webb DJ, MacLellan A, Young A, Byrne B, Robson L, Smyth JF, Jodrell DI. Forearm blood flow and local responses to peptide vasodilators: a novel pharmacodynamic measure in the phase I trial of antagonist G, a neuropeptide growth factor antagonist. Clin Cancer Res. 2001 Oct;7(10):3071-8. PubMed PMID: 11595697. 3. Moreira JN, Gaspar R. Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer. Braz J Med Biol Res. 2004 Aug;37(8):1185-92. Epub 2004 Jul 20. PubMed PMID: 15273819. 4. Jones DA, Cummings J, Langdon SP, Smyth JF. Preclinical studies on the broad-spectrum neuropeptide growth factor antagonist G. Gen Pharmacol. 1997 Feb;28(2):183-9. Review. PubMed PMID: 9013192.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Antagonist G 115150-59-9 Arg-trp-N-methyl-phe-trp-leu-met-NH2 inhibitor inhibit

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