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Ancremonam

Catalog No. T27962 CAS 1810051-96-7

Synonyms: LYS228, LYS-228, LYS 228

LYS228 is a potent antibiotics against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM/mL). LYS228 is potent in the presence of all classes of beta-lactamases.

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Ancremonam, CAS 1810051-96-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

LYS228 is a potent antibiotics against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM/mL). LYS228 is potent in the presence of all classes of beta-lactamases.

Synonyms	LYS228, LYS-228, LYS 228
Molecular Weight	518.48
Formula	C16H18N6O10S2
CAS No.	1810051-96-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Klingen AR, Palsdottir H, Hunte C, Ullmann GM. Redox-linked protonation state changes in cytochrome bc1 identified by Poisson-Boltzmann electrostatics calculations. Biochim Biophys Acta. 2007 Mar;1767(3):204-21. Epub 2007 Jan 31. PubMed PMID: 17349966. 2. Rosell A, Valencia E, Ochoa WF, Fita I, Parés X, Farrés J. Complete reversal of coenzyme specificity by concerted mutation of three consecutive residues in alcohol dehydrogenase. J Biol Chem. 2003 Oct 17;278(42):40573-80. Epub 2003 Aug 4. PubMed PMID: 12902331. 3. Rosell A, Valencia E, Parés X, Fita I, Farrés J, Ochoa WF. Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8). J Mol Biol. 2003 Jun 27;330(1):75-85. PubMed PMID: 12818203. 4. Shimizu T, Nakatsu T, Miyairi K, Okuno T, Kato H. Active-site architecture of endopolygalacturonase I from Stereum purpureum revealed by crystal structures in native and ligand-bound forms at atomic resolution. Biochemistry. 2002 May 28;41(21):6651-9. PubMed PMID: 12022868.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ancremonam 1810051-96-7 LYS228 LYS-228 LYS 228 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.