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Anacardic Acid

Name: Anacardic Acid
Brand: TargetMol
SKU: T6389
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6389Cas No. 16611-84-0

Alias Hydroginkgolic acid, 6-pentadecylsalicylic Acid

Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.

Anacardic Acid

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Purity: 99.87%

Catalog No. T6389Alias Hydroginkgolic acid, 6-pentadecylsalicylic AcidCas No. 16611-84-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$144	In Stock	In Stock
50 mg	$216	In Stock	In Stock
100 mg	$325	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.87%

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.
Targets&IC50	PCAF(p300/CREB-binding protein-associated factor):5 μM, p300 HAT:8.5 μM
In vitro	Anacardic acid is an inhibitor of several Clinicalally targeted enzymes such as HATs, NF-kB, LOX-1, xanthine oxidase, tyrosinase, and ureases. Anacardic acid is also an effective inhibitor of Tip60 in vitro. It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells and sensitizes the cells to the cytotoxic effects of radiation.
In vivo	Anacardic acid decreases over-expression of Gata4, α-MHC, and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of PCAF, P300 to the promoter of Gata4.
Kinase Assay	HAT and HDAC Activity Assays :After homogenization of cardiac tissues, nucleoproteins are extracted using a Nuclear Extract Kit according to the manufacturer's instructions. HAT and HDAC activities of the nuclear protein extracts are determined using a colorimetric assay included in the HAT and HDAC assay kits.
Cell Research	HeLa and 293T cells are grown in Dulbecco's modified Eagle's medium/10% fetal calf serum. SQ20B and SCC35 squamous cell carcinoma cell lines are cultured in modified eagles medium/10% fetal calf serum. For anacardic acid (EMD Biosciences, CA) exposure, cells are preincubated with anacardic acid (0-100 μM) for 40 min, irradiated, then allowed to recover for 4 h. Cells are then switched to fresh media and allowed to grow for 10 days.
Animal Research	Animal Models: 9 to 11 week old Kunming mice. Formulation: Dissolved in DMSO,co-injected with ethanol. Dosages: 0,1.25,2.5,5,10 mg/kg. Administration: i.p.
Synonyms	Hydroginkgolic acid, 6-pentadecylsalicylic Acid

Chemical Properties

Molecular Weight	348.52
Formula	C₂₂H₃₆O₃
Cas No.	16611-84-0
Smiles	CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
Relative Density.	1.002 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 17.4 mg/mL (49.93 mM), Sonication is recommended.

DMSO: 252 mg/mL (723.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8693 mL	14.3464 mL	28.6928 mL	143.4638 mL
5 mM	0.5739 mL	2.8693 mL	5.7386 mL	28.6928 mL
10 mM	0.2869 mL	1.4346 mL	2.8693 mL	14.3464 mL
20 mM	0.1435 mL	0.7173 mL	1.4346 mL	7.1732 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0574 mL	0.2869 mL	0.5739 mL	2.8693 mL
100 mM	0.0287 mL	0.1435 mL	0.2869 mL	1.4346 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc