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Anamorelin

Name: Anamorelin
Brand: TargetMol
SKU: T10319
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: RC-1291, ONO-7643) Copy Product Info

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Synonyms: RC-1291, ONO-7643

Catalog No. T10319 Copy Product Info

Purity: 99.94%

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Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).

Cas No. 249921-19-5

Pack Size	Price	USA Stock	Global Stock
5 mg	$55	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$187	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
Targets & IC50	Ghrelin receptor:（EC50）0.74 nM , Ghrelin receptor:（ki）0.7 nM
In vitro	Anamorelin(ANAM) is a potent and highly specific ghrelin receptor agonist
In vivo	Anamorelin(ANAM) showed significant agonist and binding activity on the ghrelin receptor, and stimulated GH release in vitro.?In rats, ANAM significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses.?Increases in GH and IGF-1 levels were observed following ANAM administration in pigs.
Synonyms	RC-1291, ONO-7643

Chemical Properties

Molecular Weight	546.7
Formula	C₃₁H₄₂N₆O₃
Cas No.	249921-19-5
Smiles	CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
Relative Density.	1.214 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 250 mg/mL (457.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (18.29 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (18.29 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8292 mL	9.1458 mL	18.2916 mL	91.4578 mL
5 mM	0.3658 mL	1.8292 mL	3.6583 mL	18.2916 mL
10 mM	0.1829 mL	0.9146 mL	1.8292 mL	9.1458 mL
20 mM	0.0915 mL	0.4573 mL	0.9146 mL	4.5729 mL
50 mM	0.0366 mL	0.1829 mL	0.3658 mL	1.8292 mL
100 mM	0.0183 mL	0.0915 mL	0.1829 mL	0.9146 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc