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Amoxapine

Catalog No. T1568   CAS 14028-44-5
Synonyms: CL-67772

Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.

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Amoxapine Chemical Structure
Amoxapine, CAS 14028-44-5
Pack Size Availability Price/USD Quantity
500 mg In stock $ 64.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 98.84%
Purity: 98.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
Targets&IC50 GlyT1b:1 mM, GlyT2a:92 μM
Synonyms CL-67772
Molecular Weight 313.78
Formula C17H16ClN3O
CAS No. 14028-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (31.87 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Núñez E, et al. Br J Pharmacol. 2000 Jan;129(1):200-6. 2. Obers S, et al. Naunyn Schmiedebergs Arch Pharmacol, 2010, 381(5), 385-400. 3. Hamon M, et al. Neuropharmacology, 1987, 26(6), 531-539. 4. Maudhuit C, et al. Neuropharmacology, 1994, 33(8), 12017-1025. 5. Greenblatt EN, et al. Arch Int Pharmacodyn Ther, 1978, 233(1), 107-135.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Glutamine Metabolism Compound Library Bioactive Compounds Library Max Drug Repurposing Compound Library Approved Drug Library Immunology/Inflammation Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library ReFRAME Related Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets
Bitopertin (R enantiomer) Opiranserin hydrochloride ASP2535 Sarcosine ALX-1393 Org 25543 hydrochloride Bitopertin PF-03463275

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Keywords

Amoxapine 14028-44-5 Neuroscience GlyT inhibit Inhibitor CL-67772 CL 67772 CL67772 inhibitor

 

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