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Amfenac sodium

Catalog No. T20197 CAS 61941-56-8

Synonyms: AHR5850, AHR 5850

Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.

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Amfenac sodium, CAS 61941-56-8

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.

Synonyms	AHR5850, AHR 5850
Molecular Weight	277.26
Formula	C15H12NNaO3
CAS No.	61941-56-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Sheppard JD, Cockrum PC, Justice A, Jasek MC. In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits. Ophthalmol Ther. 2018 May 14. doi: 10.1007/s40123-018-0130-1. [Epub ahead of print] PubMed PMID: 29761367. 2. Acar U, Acar DE, Tanriverdi C, Acar M, Ozdemir O, Erikci A, Ornek F. Prostaglandin E(2) Levels of Aqueous and Vitreous Humor in Ketorolac 0.4% and Nepafenac 0.1% Administered Healthy Rabbits. Ocul Immunol Inflamm. 2017 Jun;25(3):323-327. doi: 10.3109/09273948.2015.1116587. Epub 2016 Jan 14. PubMed PMID: 26765265. 3. Chastain JE, Sanders ME, Curtis MA, Chemuturi NV, Gadd ME, Kapin MA, Markwardt KL, Dahlin DC. Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye. Exp Eye Res. 2016 Apr;145:58-67. doi: 10.1016/j.exer.2015.10.009. Epub 2015 Oct 22. PubMed PMID: 26474497. 4. Kida T, Kozai S, Takahashi H, Isaka M, Tokushige H, Sakamoto T. Pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs in retinochoroidal tissues in rabbits. PLoS One. 2014 May 5;9(5):e96481. doi: 10.1371/journal.pone.0096481. eCollection 2014. PubMed PMID: 24796327; PubMed Central PMCID: PMC4010472.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amfenac sodium 61941-56-8 AHR5850 AHR-5850 AHR 5850 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.