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Ambrisentan sodium

Catalog No. T61921 CAS 1386915-48-5

Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).

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Ambrisentan sodium, CAS 1386915-48-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).
In vitro	Ambrisentan sodium, an endothelin type A receptor antagonist [1], promotes Nrf2 activation. It mitigates the increase in endothelial permeability observed in BMEC monolayers after 24 hours of hypoxia, compared to a vehicle control. However, this protective effect of Ambrisentan is negated when BMEC are pre-treated with siRNA targeting Nrf2 [2].
In vivo	In the study, Ambrisentan treatment resulted in a notably lower hepatic hydroxyproline content compared to the control (18.0 μg/g±6.1 μg/g vs 33.9 μg/g±13.5 μg/g liver, P=0.014). Furthermore, assessments of hepatic fibrosis using Sirius red staining and the evaluation of areas positive for α-smooth muscle actin—a marker of hepatic stellate cell activation—revealed significant reductions in the Ambrisentan group (0.46%±0.18% vs 1.11%±0.28%, P=0.0003; and 0.12%±0.08% vs 0.25%±0.11%, P=0.047, respectively). Additionally, hepatic RNA expression levels of procollagen-1 and tissue inhibitor of metalloproteinase-1 (TIMP-1) were reduced by 60% and 45%, respectively, in the Ambrisentan-treated group. It's important to note that Ambrisentan sodium's effect on inflammation, steatosis, and endothelin-related mRNA expression in the liver was not significant between groups. The findings suggest that Ambrisentan sodium mitigates hepatic fibrosis progression through the inhibition of hepatic stellate cell activation and a decrease in procollagen-1 and TIMP-1 gene expression, without influencing inflammation or steatosis.

Molecular Weight	400.41
Formula	C22H21N2NaO4
CAS No.	1386915-48-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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Ambrisentan sodium 1386915-48-5 inhibitor inhibit

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