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Alyssin

Catalog No. T26605 CAS 646-23-1

Alyssin is a sulforaphane homolog and antioxidant. It induces phase II enzymes and increases Nrf2 levels in adenocarcinoma cells. It decreases the metabolism of polycyclic aromatic hydrocarbons, supressing the risk of carcinogenesis in vitro.

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Alyssin, CAS 646-23-1

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 240.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	191.31
Formula	C7H13NOS2
CAS No.	646-23-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lubelska K, Misiewicz-Krzemińska I, Milczarek M, Krzysztoń-Russjan J, Anuszewska E, Modzelewska K, Wiktorska K. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. doi: 10.1007/s11010-012-1314-y. Epub 2012 Apr 18. PubMed PMID: 22527941. 2. Skupinska K, Misiewicz-Krzeminska I, Lubelska K, Kasprzycka-Guttman T. The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. Toxicol In Vitro. 2009 Aug;23(5):763-71. doi: 10.1016/j.tiv.2009.04.001. Epub 2009 Apr 9. PubMed PMID: 19362136. 3. Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, Lubelska K, Kasprzycka-Guttman T. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. doi: 10.1002/jbt.20259. PubMed PMID: 19202560. 4. Misiewicz I, Skupinska K, Kasprzycka-Guttman T. Differential response of human healthy lymphoblastoid and CCRF-SB leukemia cells to sulforaphane and its two analogues: 2-oxohexyl isothiocyanate and alyssin. Pharmacol Rep. 2007 Jan-Feb;59(1):80-7. PubMed PMID: 17377210.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alyssin 646-23-1 inhibitor inhibit

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