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Alvameline maleate

Catalog No. T14197L CAS 219581-36-9

Synonyms: Lu 25-109-M

Alvameline maleate is used as a Partial M1 Agonist and M2/M3 Antagonist.

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Alvameline maleate, CAS 219581-36-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Alvameline maleate is used as a Partial M1 Agonist and M2/M3 Antagonist.

Synonyms	Lu 25-109-M
Molecular Weight	309.32
Formula	C13H19N5O4
CAS No.	219581-36-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tapia E, Sánchez-Lozada LG, García-Niño WR, García E, Cerecedo A, García-Arroyo FE, Osorio H, Arellano A, Cristóbal-García M, Loredo ML, Molina-Jijón E, Hernández-Damián J, Negrette-Guzmán M, Zazueta C, Huerta-Yepez S, Reyes JL, Madero M, Pedraza-Chaverrí J. Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Free Radic Res. 2014 Nov;48(11):1342-54. doi: 10.3109/10715762.2014.954109. Epub 2014 Sep 9. PubMed PMID: 25119790. 2. Liu K, Xu Y, Zhou NY. Identification of a Specific Maleate Hydratase in the Direct Hydrolysis Route of the Gentisate Pathway. Appl Environ Microbiol. 2015 Sep 1;81(17):5753-60. doi: 10.1128/AEM.00975-15. Epub 2015 Jun 12. PubMed PMID: 26070679; PubMed Central PMCID: PMC4551245. 3. Erythropel HC, Brown T, Maric M, Nicell JA, Cooper DG, Leask RL. Designing greener plasticizers: Effects of alkyl chain length and branching on the biodegradation of maleate based plasticizers. Chemosphere. 2015 Sep;134:106-12. doi: 10.1016/j.chemosphere.2015.04.014. Epub 2015 Apr 27. PubMed PMID: 25917507. 4. Tsai CF, Wu GY, Kuo CH, Lin YW, Chang CH, Tseng SH, Kao YM, Chiueh LC, Lu TJ, Shih DY. Effective extraction method through alkaline hydrolysis for the detection of starch maleate in foods. J Food Drug Anal. 2015 Sep;23(3):442-446. doi: 10.1016/j.jfda.2014.09.002. Epub 2015 Jan 2. PubMed PMID: 28911701.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alvameline maleate 219581-36-9 Lu 25-109-M Alvameline Maleate inhibitor inhibit

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