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Acotiamide monohydrochloride trihydrate

Catalog No. T2319 CAS 773092-05-0

Synonyms: YM-443 HCl, Z-338 HCl, Acotiamide hydrochloride

Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AChE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

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Acotiamide monohydrochloride trihydrate, CAS 773092-05-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Synonyms	YM-443 HCl, Z-338 HCl, Acotiamide hydrochloride
Molecular Weight	541.06
Formula	C21H37ClN4O8S
CAS No.	773092-05-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 27.5 mg/mL (50.83 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kawachi M,et al. Eur J Pharmacol. 2011 Sep;666(1-3):218-25.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acotiamide monohydrochloride trihydrate 773092-05-0 Neuroscience AChE functional dyspepsia intestinal inflammatory YM-443 HCl NR8383 Acotiamide monohydrochloride inhibit macrophage Z-338 HCl gastric emptying Acotiamide hydrochloride Cholinesterase (ChE) Inhibitor gastric motility inhibitor

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