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Aclerastide

Catalog No. T26554 CAS 227803-63-6

Synonyms: DSC-127, DSC 127, NorLeu-3-A(1-7), DSC127, NorLeu-3A(1-7)

Aclerastide is an angiotensin receptor agonist. Administration of Aclerastide reduced fibrosis and scarring in the healing wounds. This action was more pronounced with longer administration of the peptide after injury. The action of this peptide was blocked by the AT receptor antagonist d-Ala7-angiotensin(1-7), which suggests that this receptor is involved in the healing responses to exogenous Aclerastide.

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Aclerastide, CAS 227803-63-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DSC-127, DSC 127, NorLeu-3-A(1-7), DSC127, NorLeu-3A(1-7)
Molecular Weight	913.03
Formula	C42H64N12O11
CAS No.	227803-63-6

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Abdallah WF, Louie SG, Zhang Y, Rodgers KE, Sivok E, S diZerega G, Humayun MS. NorLeu3A(1-7) Accelerates Clear Corneal Full Thickness Wound Healing. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2187-94. doi: 10.1167/iovs.15-18515. PubMed PMID: 27116546. 2. Singh N, Joshi S, Guo L, Baker MB, Li Y, Castellano RK, Raizada MK, Jarajapu YP. ACE2/Ang-(1-7)/Mas axis stimulates vascular repair-relevant functions of CD34+ cells. Am J Physiol Heart Circ Physiol. 2015 Nov 15;309(10):H1697-707. doi: 10.1152/ajpheart.00854.2014. Epub 2015 Sep 18. PubMed PMID: 26386115; PubMed Central PMCID: PMC4666983. 3. Rodgers KE, Bolton LL, Verco S, diZerega GS. NorLeu(3)-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers. Adv Wound Care (New Rochelle). 2015 Jun 1;4(6):339-345. Review. PubMed PMID: 26029484; PubMed Central PMCID: PMC4440979. 4. Balingit PP, Armstrong DG, Reyzelman AM, Bolton L, Verco SJ, Rodgers KE, Nigh KA, diZerega GS. NorLeu3-A(1-7) stimulation of diabetic foot ulcer healing: results of a randomized, parallel-group, double-blind, placebo-controlled phase 2 clinical trial. Wound Repair Regen. 2012 Jul-Aug;20(4):482-90. doi: 10.1111/j.1524-475X.2012.00804.x. Epub 2012 Jun 7. PubMed PMID: 22672145.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aclerastide 227803-63-6 DSC-127 NorLeu-3A DSC 127 NorLeu-3-A(1-7) DSC127 NorLeu-3A(1-7) NorLeu-3-A inhibitor inhibit

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