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Abeprazan hydrochloride

Catalog No. T10221 CAS 1902954-87-3

Synonyms: DWP14012 hydrochloride, Fexuprazan hydrochloride

Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers.

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Abeprazan hydrochloride Chemical Structure

Abeprazan hydrochloride, CAS 1902954-87-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 157.00
5 mg	In stock	$ 397.00
10 mg	In stock	$ 589.00
25 mg	In stock	$ 945.00
50 mg	In stock	$ 1,280.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,460.00

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Purity: 98.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
In vitro	The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].
In vivo	Abeprazan hydrochloride effectively suppresses acid secretion in a dose-responsive manner, demonstrating equal or superior efficacy to vonoprazan, an established P-CAB, across multiple in vivo studies including pylorus-ligated rats, lumen-perfused rat models, and Heidenhain pouch dog models[1].

Synonyms	DWP14012 hydrochloride, Fexuprazan hydrochloride
Molecular Weight	446.87
Formula	C19H18ClF3N2O3S
CAS No.	1902954-87-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (50.4 mM), Sonication is recommended.

References and Literature

1. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Exosome Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library Mitochondria-Targeted Compound Library

Related Products

Related compounds with same targets

(R)-Lansoprazole Lansoprazole Sulfide D4 Pantoprazole Pantoprazole Sodium Hydrate Esomeprazole Bamaquimast Chebulinic acid Esomeprazole Magnesium

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Abeprazan hydrochloride 1902954-87-3 Membrane transporter/Ion channel Proton pump Fexuprazan Hydrochloride Abeprazan Hydrochloride DWP-14012 Hydrochloride DWP 14012 Hydrochloride DWP14012 Hydrochloride DWP14012 hydrochloride Fexuprazan hydrochloride inhibitor inhibit

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