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AX-15836

Name: AX-15836
Brand: TargetMol
SKU: T14360
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14360Cas No. 2035509-96-5

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

AX-15836

😃Good

Purity: 98.96%

Catalog No. T14360Cas No. 2035509-96-5

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
2 mg	$74	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$446	In Stock	In Stock
100 mg	$629	In Stock	In Stock
500 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
Targets&IC50	ERK5:8 nM
In vitro	AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases and it also shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells[1].

Chemical Properties

Molecular Weight	648.78
Formula	C₃₂H₄₀N₈O₅S
Cas No.	2035509-96-5
Smiles	CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(c2n1)S(C)(=O)=O)C(=O)N1CCC(CC1)N1CCN(C)CC1
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (154.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5414 mL	7.7068 mL	15.4135 mL	77.0677 mL
5 mM	0.3083 mL	1.5414 mL	3.0827 mL	15.4135 mL
10 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7068 mL
20 mM	0.0771 mL	0.3853 mL	0.7707 mL	3.8534 mL
50 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL
100 mM	0.0154 mL	0.0771 mL	0.1541 mL	0.7707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc