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AT791

Catalog No. T61882 CAS 1219962-49-8

AT791 is an effective TLR7 and TLR9 inhibitor with oral activity. AT791 has inhibitory effects on TLR7 and TLR9 signal transduction in various types of human and mouse cells. AT791 inhibits DNA-TLR9 interaction in vitro.

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AT791, CAS 1219962-49-8

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 297.00
25 mg	6-8 weeks	$ 916.00
50 mg	6-8 weeks	$ 1,190.00
100 mg	6-8 weeks	$ 1,860.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 296.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AT791 is an effective TLR7 and TLR9 inhibitor with oral activity. AT791 has inhibitory effects on TLR7 and TLR9 signal transduction in various types of human and mouse cells. AT791 inhibits DNA-TLR9 interaction in vitro.
In vitro	AT791 effectively inhibits DNA-induced activation of HEK:TLR9 cells, demonstrating a potent suppression with an IC 50 of 0.04 μM, whereas its suppression of R848-induced activation in HEK:TLR7 cells is notably less potent (IC 50 = 3.33 μM). Similarly, AT7916 blocks the interaction between TLR9 and DNA in vitro, achieving an IC 50 within the range of 1 to 10 μM. Both AT791 and E6446 exemplify the characteristics of lysosomotropic compounds, being lipophilic and containing weak base amines, which allow them to cross lipid membranes easily at a neutral pH. Inside low pH vesicles, these compounds become protonated and are retained. Through capillary electrophoresis, it has been identified that AT791 possesses pKa values of 7.9 and 6.1, whereas E6446 shows pKa values of 8.6 and 6.5. These results suggest that both compounds are more prone to protonation within endolysosomal compartments than in the cytoplasm, supporting their mechanism of action.
In vivo	Pretreatment with AT791 (20 mg/kg; p.o.) [1] effectively suppresses the short-term induction of serum interleukin-6 in mice induced by CpG1668 DNA.

Molecular Weight	397.51
Formula	C23H31N3O3
CAS No.	1219962-49-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AT791 1219962-49-8 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.