Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively). Exhibits <4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 1,230.00 |
Description | Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant. |
Molecular Weight | 472.42 |
Formula | C22H19F3N6O3 |
CAS No. | 939040-79-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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AMG 21629 939040-79-6 AMG21629 AMG-21629 inhibitor inhibit