Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 1,860.00 |
Description | AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM). |
Targets&IC50 | Human neutrophil elastase:29 nM |
In vitro | AE-3763 has potent inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water. |
In vivo | Edema and leukocytes infiltration into the lung is significantly inhibited by the infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 (300 mg/kg, i.v.) in mice, the results of a preliminary study have shown no overt toxic effect. |
Animal Research | D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. The animal survival rate is observed up to 24 h after shock induction. |
Molecular Weight | 549.54 |
Formula | C23H34F3N5O7 |
CAS No. | 291778-77-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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AE-3763 291778-77-3 Proteases/Proteasome Serine Protease AE3763 AE 3763 Inhibitor inhibitor inhibit