Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-335827 is an orally available, brain-penetrant orexin type 1 receptor selective antagonist. ACT-33582 acts on OXR1 and OXR2 with IC 50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 35 days | $ 1,140.00 | |
50 mg | 35 days | $ 4,600.00 |
Description | ACT-335827 is an orally available, brain-penetrant orexin type 1 receptor selective antagonist. ACT-33582 acts on OXR1 and OXR2 with IC 50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders [1]. |
In vitro | ACT-335827 (0-10 μM, 2 h) is active on OXR-1 and OXR-2 with the Kb values of 41 nM and 560 nM, the IC 50 values of 120 nM and 2300 nM, respectively in CHO cells [1]. |
In vivo | ACT-335827 administered through oral gavage at doses ranging from 30-100 mg/kg once, effectively reduces the fear-induced startle response in rats, without impacting their motor or cognitive functions [1]. In contrast, continuous oral administration of ACT-335827 at a dose of 300 mg/kg daily for four weeks shows diminished effects on metabolic syndrome (MetS) symptoms, such as diet-induced obesity (DIO), in male Wistar rats [2]. Notably, the compound at 300 mg/kg reduces the preferential selection for high fat/sweet diets, increases water intake, and elevates HDL levels relative to total cholesterol, all while only resulting in a modest 4% weight gain compared with control subjects. Furthermore, it's reported that a 300 mg/kg dosage can diminish stress-induced elevations in body temperature and accelerate heart rate at both the 100 and 300 mg/kg doses, with no observable effects on locomotion and blood pressure. |
Molecular Weight | 518.64 |
Formula | C31H38N2O5 |
CAS No. | 1354039-86-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ACT 335827 1354039-86-3 ACT335827 ACT-335827 inhibitor inhibit