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Home > Cytoskeletal Signaling > Akt > A-674563 HCl (552325-73-2(free base))

A-674563 HCl (552325-73-2(free base))

Catalog No. T4444    CAS T4444   

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].

Pack Size Availability Price/USD Quantity
1 mg Inquiry 86.00
2 mg Inquiry 124.00
5 mg Inquiry 156.00
10 mg Inquiry 219.00
25 mg Inquiry 394.00
50 mg Inquiry 590.00
100 mg Inquiry 886.00
1 mL * 10 mM (in DMSO) Inquiry 156.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].

Receptor:

Akt1; CDK2; PKA;

Chemical Information:
Molecular Weight 394.90
Formula C22H23ClN4O
CAS Number T4444
Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.