Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A-83586C also inhibits E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb).
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Description | A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A-83586C also inhibits E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb). |
Synonyms | A83586C, A-83586C |
Molecular Weight | 977.15 |
Formula | C47H76N8O14 |
CAS No. | 116364-81-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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A 83586C 116364-81-9 A83586C A-83586C inhibitor inhibit