Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI).The activity of phosphoglucose isomerase was inhibited intensely and competitively by 6-Phosphogluconic acid, with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate.
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Description | 6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI).The activity of phosphoglucose isomerase was inhibited intensely and competitively by 6-Phosphogluconic acid, with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate. |
Targets&IC50 | Fructose 6-phosphate:42 μM(Ki), Glucose 6-phosphate:48 μM(Ki) |
In vitro | 6-Phosphogluconic acid, at concentrations ranging from 0.5 to 2.0 mM, fully inhibits the activity of phosphoglucose isomerase (PGI) when using glucose 6-phosphate, in concentrations of 0.05 to 0.5 mM, as the substrate [1]. |
Molecular Weight | 276.14 |
Formula | C6H13O10P |
CAS No. | 921-62-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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6-Phosphogluconic acid 921-62-0 Metabolism Others Endogenous Metabolite Inhibitor glucose PGI 6Phosphogluconic acid inhibit fructose isomerase 6-phosphate 6 Phosphogluconic acid phosphoglucose inhibitor