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5,6-Dihydroxyindole

Catalog No. T10164 CAS 3131-52-0

Synonyms: Dopamine lutine

5,6-Dihydroxyindole (Dopamine lutine) is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity. It has cytotoxic effects and is strongly toxic against various pathogens.

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5,6-Dihydroxyindole, CAS 3131-52-0

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100 mg	In stock	$ 29.00

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Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) demonstrably reduces OD492 values in a dose-dependent manner. When Sf9 cells are pre-treated with 1.0 mM 5,6-Dihydroxyindole for 4 hours, there is a significant mortality rate of 97%, with LC50 values reported at 20.3 μM in buffer and 131.8 μM in culture medium, respectively. Additionally, pre-incubating a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours almost completely inhibits the production of recombinant proteins. The compound also shows biological activity against lambda bacteriophage and wasp eggs (Microplitis demolitor), with LC50 values of 5.6 μM and 111.0 μM, respectively. Furthermore, both 5,6-Dihydroxyindole and its spontaneous oxidation products exhibit efficacy against viruses and parasitic wasps [1].

Synonyms	Dopamine lutine
Molecular Weight	149.15
Formula	C8H7NO2
CAS No.	3131-52-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 45.0 mg/mL (301.7 mM), Sonication is recommended.

References and Literature

1. Zhao P, et al. Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response. Insect Biochem Mol Biol. 2011 Sep;41(9):645-52. 2. Heiduschka P, et al. Melanin precursor 5,6-dihydroxyindol: protective effects and cytotoxicity on retinal cells in vitroand in vivo. Toxicol Pathol. 2007 Dec;35(7):1030-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Antiparasitic Natural Product Library Anti-Viral Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

5,6-Dihydroxyindole 3131-52-0 Metabolism Endogenous Metabolite Dopamine lutine inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.