Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs). NS3861 fumarate is a partial agonist at α3β4 nAChR and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 49.00 |
Description | NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs). NS3861 fumarate is a partial agonist at α3β4 nAChR and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1]. |
In vitro | NS3861 fumarate demonstrates selectivity by activating α3-containing nicotinic acetylcholine receptors (nAChRs) while showing no activation in α4-containing receptors in HEK293 cell lines. It exhibits a clear preference, acting as a stronger agonist on α3β2 receptors (EC 50 of 0.15 μM) compared to α3β4 receptors (EC 50 of 1.7 μM) and possesses high affinity and partial agonist characteristics for α3β4-expressed nAChRs [2]. This compound presents an inverse β-subunit preference, emphasizing its distinctive interaction with nAChR subtypes [1]. |
In vivo | NS3861 fumarate dose-dependently enhances fecal pellet expulsion in mice that received long-term morphine treatment [2]. |
Molecular Weight | 400.29 |
Formula | C16H18BrNO4S |
CAS No. | 216853-60-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NS3861 fumarate 216853-60-0 3(3Bromo2thienyl)8methyl8azabicyclo[3.2.1]oct2ene fumarate 3 (3 Bromo 2 thienyl) 8 methyl 8 azabicyclo[3.2.1]oct 2 ene fumarate NS-3861 Fumarate NS 3861 Fumarate NS3861 Fumarate inhibitor inhibit