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3β-Ursodeoxycholic acid

Name: 3β-Ursodeoxycholic acid
Brand: TargetMol
SKU: T13506
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13506Cas No. 78919-26-3

Alias Isoursodeoxycholic acid

3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid that exhibits good tolerance and good intestinal absorption when administered orally.3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can undergo enzymatic isomerization in the intestines and the 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) undergoes enzymatic isomerization in the intestine and liver and produces UDCA.

3β-Ursodeoxycholic acid

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Purity: 99.89%

Catalog No. T13506Alias Isoursodeoxycholic acidCas No. 78919-26-3

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$139	In Stock
25 mg	$272	In Stock
50 mg	$419	In Stock
100 mg	$612	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Purity:99.89%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid that exhibits good tolerance and good intestinal absorption when administered orally.3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can undergo enzymatic isomerization in the intestines and the 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) undergoes enzymatic isomerization in the intestine and liver and produces UDCA.
In vitro	METHODS: Hep G2 cells were treated with 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) (100 μM) and ethanol (80 μM) to investigate the effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells. The cytotoxic effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells were investigated, as well as the interactions between them. RESULTS 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) did not show any cytotoxic effects and could be cytoprotective against ethanol-induced cell damage. [4] Translated with DeepL.com (free version)
In vivo	METHODS: 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) or UDCA (2.5 g/kg, orally, for 3 weeks) were given to rats , respectively , to compare the metabolism of UDCA and 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) in experimental cholestasis and the effects on cholestasis in rats. RESULTS3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) was completely converted to UDCA in the liver; cholestasis and cholestatic bile acids were identical after intraduodenal administration of either compound. Oral administration of UDCA or 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) significantly improved hepatic biochemistry in chronic cholestasis, but not clinical and histologic parameters. [1] Translated with DeepL.com (free version)
Synonyms	Isoursodeoxycholic acid

Chemical Properties

Molecular Weight	392.57
Formula	C₂₄H₄₀O₄
Cas No.	78919-26-3
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C[C@@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
Relative Density.	1.128 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (229.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5473 mL	12.7366 mL	25.4732 mL	127.3658 mL
5 mM	0.5095 mL	2.5473 mL	5.0946 mL	25.4732 mL
10 mM	0.2547 mL	1.2737 mL	2.5473 mL	12.7366 mL
20 mM	0.1274 mL	0.6368 mL	1.2737 mL	6.3683 mL
50 mM	0.0509 mL	0.2547 mL	0.5095 mL	2.5473 mL
100 mM	0.0255 mL	0.1274 mL	0.2547 mL	1.2737 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc