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3,8''-Biapigenin
(Synonyms: 3,8'-Biapigenin) Copy Product Info
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Synonyms: 3,8'-Biapigenin
Catalog No. TN1241 Copy Product Info
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3,8'-Biapigenin is a polyketide synthase-derived biflavonoid identified in Hypericum species and has been reported to exhibit diverse biological activities. 3,8'-Biapigenin inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 4.5 µM and stimulates glucose uptake in 3T3-L1 adipocyte cells at concentrations of 5 and 10 µM. 3,8'-Biapigenin also inhibits the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP1A2, with Ki values of 0.038, 0.32, and 0.95 µM, respectively. In isolated rat embryonic hippocampal neurons, 3,8'-Biapigenin reverses cell death induced by kainate and NMDA when applied at a concentration of 10 µM. Furthermore, 3,8'-Biapigenin administered at 8 mg/kg decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats. These findings support the application of 3,8'-Biapigenin as a research tool for investigations involving metabolic regulation, enzyme modulation, neurobiology, inflammatory processes, and xenobiotic metabolism.
Cas No. 101140-06-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $255 | - | In Stock | |
| 10 mg | $378 | - | In Stock | |
| 25 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3,8'-Biapigenin is a polyketide synthase-derived biflavonoid identified in Hypericum species and has been reported to exhibit diverse biological activities. 3,8'-Biapigenin inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 4.5 µM and stimulates glucose uptake in 3T3-L1 adipocyte cells at concentrations of 5 and 10 µM. 3,8'-Biapigenin also inhibits the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP1A2, with Ki values of 0.038, 0.32, and 0.95 µM, respectively. In isolated rat embryonic hippocampal neurons, 3,8'-Biapigenin reverses cell death induced by kainate and NMDA when applied at a concentration of 10 µM. Furthermore, 3,8'-Biapigenin administered at 8 mg/kg decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats. These findings support the application of 3,8'-Biapigenin as a research tool for investigations involving metabolic regulation, enzyme modulation, neurobiology, inflammatory processes, and xenobiotic metabolism. |
| Synonyms | 3,8'-Biapigenin |
| Molecular Weight | 538.46 |
| Formula | C30H18O10 |
| Cas No. | 101140-06-1 |
| Smiles | O=C1C=C(OC2=C1C(O)=CC(O)=C2C=3C(=O)C=4C(O)=CC(O)=CC4OC3C=5C=CC(O)=CC5)C=6C=CC(O)=CC6 |
| Relative Density. | 1.672 g/cm3 (Predicted) |
| Storage | Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (74.29 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: 3,8''-Biapigenin chemical structure | 3,8''-Biapigenin formula | 3,8''-Biapigenin molecular weight
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