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2MeSAMP

Catalog No. T24975 CAS 81921-45-1

Synonyms: 2 MeS AMP bis-sodium, 2-MeS-AMP bis-sodium, 2MeSAMP bis-sodium

2MeSAMP is a P2Y(12) antagonist that works by inhibiting platelet activation through a P2Y(12)/G(i)-dependent mechanism.

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2MeSAMP, CAS 81921-45-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

2MeSAMP is a P2Y(12) antagonist that works by inhibiting platelet activation through a P2Y(12)/G(i)-dependent mechanism.

Synonyms	2 MeS AMP bis-sodium, 2-MeS-AMP bis-sodium, 2MeSAMP bis-sodium
Molecular Weight	416.3
Formula	C11H16N5NaO7PS
CAS No.	81921-45-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2644-50. doi: 10.1161/ATVBAHA.114.304249. Epub 2014 Oct 2. PubMed PMID: 25278289; PubMed Central PMCID: PMC4239175. 2. Li R, Diamond SL. Detection of platelet sensitivity to inhibitors of COX-1, P2Y₁, and P2Y₁₂ using a whole blood microfluidic flow assay. Thromb Res. 2014 Feb;133(2):203-10. doi: 10.1016/j.thromres.2013.10.043. Epub 2013 Nov 6. PubMed PMID: 24365044; PubMed Central PMCID: PMC3932538. 3. Liñán-Rico A, Wunderlich JE, Grants IS, Frankel WL, Xue J, Williams KC, Harzman AE, Enneking JT, Cooke HJ, Christofi FL. Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis. Inflamm Bowel Dis. 2013 Oct;19(11):2366-79. doi: 10.1097/MIB.0b013e31829ecf4d. PubMed PMID: 23917247; PubMed Central PMCID: PMC4037929. 4. Herfindal L, Nygaard G, Kopperud R, Krakstad C, Døskeland SO, Selheim F. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8. doi: 10.1016/j.bbrc.2013.07.007. Epub 2013 Jul 12. PubMed PMID: 23850619.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2MeSAMP 81921-45-1 2 MeS AMP bis-sodium 2-MeS-AMP bis-sodium 2MeSAMP bis-sodium inhibitor inhibit

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