Shopping Cart

Your shopping cart is currently empty

2-Mercaptobenzothiazole

Name: 2-Mercaptobenzothiazole
Brand: TargetMol
SKU: T19856
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T19856Cas No. 149-30-4

Alias Mercaptobenzothiazole, Dermacid, Captax

2-Mercaptobenzothiazole (Captax) is an organosulfur compound. 2-Mercaptobenzothiazole is used in rubber vulcanization.

2-Mercaptobenzothiazole

Copy Product Info

😃Good

Purity: 98.87%

Catalog No. T19856Alias Mercaptobenzothiazole, Dermacid, CaptaxCas No. 149-30-4

2-Mercaptobenzothiazole (Captax) is an organosulfur compound. 2-Mercaptobenzothiazole is used in rubber vulcanization.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

2-Mercaptobenzothiazole AI Summary

2-Mercaptobenzothiazole demonstrates a broad spectrum of biological activities. It exhibits in vitro anti-mycobacterial activity against Mycobacterium tuberculosis and Mycobacterium kansasii with a minimum inhibitory concentration (MIC) of 62000.0 nM, although for some strains the MIC can exceed 125000.0 nM with extended incubation. Additionally, it shows antioxidant potential with DPPH and ABTS free radical scavenging activities, exhibiting IC50 values of 92000.0 nM and 79840.0 nM respectively, and high acute toxicity (LD50 > 960.0 mg/kg) in Swiss CD1 mice. 2-Mercaptobenzothiazole also provided radioprotective effects at various doses in mice subjected to gamma radiation. Furthermore, it possesses antifungal properties against Candida albicans and Aspergillus flavus, with a minimum fungicidal concentration (MFC) of 500.0 μg/ml and inhibitory concentrations (MIC) of 100.0 μg/ml and 500.0 μg/ml, respectively. The compound also shows significant inhibition of sodium fluorescein uptake and exhibits cytotoxic effects on human cancer cell lines PC3 and MCF7, with varying potency. Regarding enzyme activity, 182886 inhibits multiple targets, including Human Jumonji Domain Containing 2E (JMJD2E), Tyrosyl-DNA Phosphodiesterase (TDP1), and HDAC6, among others. It notably inhibits SARS-CoV-2 3CL-Pro protease with an IC50 of 1740.0 nM and a high inhibition percentage, while showing no significant activity against MERS 3CL-Pro protease. It also inhibited SARS-CoV-2-induced cytotoxicity in VERO-6 and Caco-2 cells. Additionally, the compound displays antiproliferative activity against human HeLa cells and inhibits the human chymotrypsin-like beta 5i subunit of iCP. Despite these diverse activities, 2-Mercaptobenzothiazole showed no significant activity against the human recombinant UGT2B7 enzyme. Collectively, these properties suggest that 2-Mercaptobenzothiazole has potential therapeutic uses across a range of biological targets and diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Mercaptobenzothiazole (Captax) is an organosulfur compound. 2-Mercaptobenzothiazole is used in rubber vulcanization.
Synonyms	Mercaptobenzothiazole, Dermacid, Captax

Chemical Properties

Molecular Weight	167.25
Formula	C₇H₅NS₂
Cas No.	149-30-4
Smiles	S=C1NC2=CC=CC=C2S1
Relative Density.	1.42 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (328.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9791 mL	29.8954 mL	59.7907 mL	298.9537 mL
5 mM	1.1958 mL	5.9791 mL	11.9581 mL	59.7907 mL
10 mM	0.5979 mL	2.9895 mL	5.9791 mL	29.8954 mL
20 mM	0.2990 mL	1.4948 mL	2.9895 mL	14.9477 mL
50 mM	0.1196 mL	0.5979 mL	1.1958 mL	5.9791 mL
100 mM	0.0598 mL	0.2990 mL	0.5979 mL	2.9895 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc