Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.
Description | Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%. |
Synonyms | 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
Molecular Weight | 574.715 |
Formula | C31H46N2O8 |
CAS No. | 1194396-71-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL
Ethanol: 10 mg/mL
You can also refer to dose conversion for different animals. More
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Bimatoprost grenod 1194396-71-8 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F-2α 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α 15 (6 nitroxyhexanoyl) 17 phenyl trinor Prostaglandin F2α 15(6nitroxyhexanoyl)17phenyl trinor Prostaglandin F2α inhibitor inhibit