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14,15-dehydro Leukotriene B4

Catalog No. T37260 CAS 114616-11-4

Synonyms: 14,15-dehydro Leukotriene B4

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.

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14,15-dehydro Leukotriene B4 Chemical Structure

14,15-dehydro Leukotriene B4, CAS 114616-11-4

Pack Size	Availability	Price/USD
25 μg	35 days	$ 345.00
50 μg	35 days	$ 653.00
100 μg	35 days	$ 1,220.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	14,15-dehydro Leukotriene B4
Molecular Weight	334.45
Formula	C20H30O4
CAS No.	114616-11-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): >1 mg/mL

DMF: Miscible

DMSO: Miscible

Ethanol: Miscible

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

14,15-dehydro Leukotriene B4 114616-11-4 14,15 dehydro Leukotriene B4 14,15-dehydro Leukotriene B-4 14,15dehydro Leukotriene B4 inhibitor inhibit

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