Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
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Description | Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres. |
In vitro | Sympathetic fibers ablation is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro [1]. |
In vivo | Guanethidine (30 mg/kg, s.c., 1 h) administration does not alter IL-18 induced hypernociception in TNFR1 (-/-) mice, indicating that this sympathetic blocker is ineffective in this context [2]. This was observed in an animal model involving wild-type (WT) Balb/c, TNFR1 (-/-), and IFN-γ (-/-) mice, with guanethidine being administered at a dosage of 30 mg/kg, delivered subcutaneously (s.c.) and diluted in saline. Despite pre-treatment with guanethidine, IL-18 hypernociception remains unaffected in TNFR1 (-/-) mice. |
Molecular Weight | 198.31 |
Formula | C10H22N4 |
CAS No. | 55-65-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Guanethidine 55-65-2 1 [2 (azocan 1 yl)ethyl]guanidine 1[2(azocan1yl)ethyl]guanidine inhibitor inhibit