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(R)-MG-132

Catalog No. T12628 CAS 1211877-36-9

Synonyms: (S,R,S)-(-)-MG-132, Z-Leu-D-leu-leu-al

(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

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(R)-MG-132, CAS 1211877-36-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 137.00
50 mg	In stock	$ 228.00
100 mg	In stock	$ 347.00
500 mg	In stock	$ 838.00
1 g	In stock	$ 1,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 98.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

In vitro

(R)-MG-132 is studied as a potential chymotrypsin-like inhibitor, trypsin-like, and peptidylglutamyl peptide hydrolyzing activities of proteasome. MG-132 and (R)-MG-132 are investigated for inhibition of ChTL, trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities of purified 20S proteasomes isolated from human erythrocytes.For (R)-MG-132, the IC50s of 0.22 μM, 34.4 μM, and 2.95 μM for ChTL, TL, and PGPH, respectively. For MG-132, the IC50s of 0.89 μM, 104.43 μM, and 5.7 μM for ChTL, TL, and PGPH, respectively.

Synonyms	(S,R,S)-(-)-MG-132, Z-Leu-D-leu-leu-al
Molecular Weight	475.62
Formula	C26H41N3O5
CAS No.	1211877-36-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (210.25 mM)

References and Literature

1. Mroczkiewicz M, et al. Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J Med Chem. 2010 Feb 25;53(4):1509-18.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Ubiquitination Compound Library Bioactive Compound Library

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Keywords

(R)-MG-132 1211877-36-9 Proteases/Proteasome Ubiquitination Proteasome MG-132 (S,R,S)-(-)-MG-132 inhibit MG132 (R)MG132 Inhibitor MG 132 Z-Leu-D-leu-leu-al (R) MG 132 inhibitor

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