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(-)-Epiafzelechin

Name: (-)-Epiafzelechin
Brand: TargetMol
SKU: TN1606
Price: 187 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN1606Cas No. 24808-04-6

(-)-Epiafzelechin is a COX inhibitor with antioxidant and anti-inflammatory activity, osteoprotective effects in a mature ovariectomized mouse model, ability to stimulate osteoblast activity and inhibit osteoclast activity.

(-)-Epiafzelechin

🥰Excellent

Purity: 99.45%

Catalog No. TN1606Cas No. 24808-04-6

Pack Size	Price	Availability
1 mg	$187	In Stock
5 mg	$396	In Stock
10 mg	$579	In Stock
25 mg	$912	In Stock

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Batch Information

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Purity:99.45%

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description	(-)-Epiafzelechin is a COX inhibitor with antioxidant and anti-inflammatory activity, osteoprotective effects in a mature ovariectomized mouse model, ability to stimulate osteoblast activity and inhibit osteoclast activity.
In vitro	(-)-Epiafzelechin exhibits significant antioxidant activity with an EC50 of 20.9μM[1].

Chemical Properties

Molecular Weight	274.27
Formula	C₁₅H₁₄O₅
Cas No.	24808-04-6
Smiles	O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)cc1
Relative Density.	1.492g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (109.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6460 mL	18.2302 mL	36.4604 mL	182.3021 mL
5 mM	0.7292 mL	3.6460 mL	7.2921 mL	36.4604 mL
10 mM	0.3646 mL	1.8230 mL	3.6460 mL	18.2302 mL
20 mM	0.1823 mL	0.9115 mL	1.8230 mL	9.1151 mL
50 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6460 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc