keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Additionally, it exhibits in vivo efficacy by suppressing experimental autoimmune encephalomyelitis (EAE) in mice. This compound has applications in researching multiple sclerosis (MS) and other neuroinflammatory diseases linked to blood-brain barrier disruption and microglial activation [1].
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5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Additionally, it exhibits in vivo efficacy by suppressing experimental autoimmune encephalomyelitis (EAE) in mice. This compound has applications in researching multiple sclerosis (MS) and other neuroinflammatory diseases linked to blood-brain barrier disruption and microglial activation [1]. |
In vitro | γ-Fibrinogen377-395 TFA (200 μM) inhibits the binding of fibrinogen to Mac-1, thereby reducing the adhesion of Mac-1 overexpressing cells to immobilized fibrinogen. Additionally, γ-Fibrinogen377-395 TFA suppresses microglial activation [1]. |
In vivo | Administration of γ-Fibrinogen377-395 TFA (30 μg/mouse; intranasal; once daily for 40 days) enhanced motor function in mice without affecting peripheral immune responses. γ-Fibrinogen377-395 did not alter the coagulation properties of fibrinogen [1]. Mice immunized with γ377-395 peptide prior to EAE induction exhibited improved motor strength and coordination compared to the control group [1]. |
Molecular Weight | N/A |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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γ-Fibrinogen 377-395 TFA inhibitor inhibit