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γ-2-MSH (41-58), amide

Catalog No. TP1532 CAS 799841-81-9

Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to 3-MSH express more than one pituitary hormone mRNA. The effect of 3-MSH is blocked by SHU9119, a MC3R and MC4R antagonist, in only 50% of the responsive cells, suggesting that in half of these cells the mediating receptor is not the MC3R. Low picomolar doses of 3-MSH increase [Ca2+]i in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line.

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γ-2-MSH (41-58), amide Chemical Structure

γ-2-MSH (41-58), amide, CAS 799841-81-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	1569.79
Formula	C74H100N22O15S
CAS No.	799841-81-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Joseph CG, et al. γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R. Peptides. 2010 Dec;31(12):2304-13.

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Keywords

γ-2-MSH (41-58), amide 799841-81-9 γ-2-MSH , Amide γ 2 MSH (41 58), amide γ2MSH (4158), amide r-2-MSH , Amide gamma-2-MSH , Amide inhibitor inhibit

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