Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-(+)-Dimethindene maleate is an orally active H 1 -receptor blocker.
Description | (R)-(+)-Dimethindene maleate is an orally active H 1 -receptor blocker. |
In vitro | (R)-(+)-Dimethindene maleate possesses membrane-stabilising effect [1]. |
In vivo | (R)-(+)-Dimethindene maleate administered orally at a dosage of 10 mL/kg once in male guinea pigs exhibited antihistaminic properties, with an effective dose (ED50) for preventing lethal histamine shock determined at 2.73 mg/kg when given one hour before histamine injection. Furthermore, the compound's oral anti-anaphylactic ED50 value exceeded 31.6 mg/kg, while its oral lethal dose (LD50) was identified as 988 mg/kg. |
Molecular Weight | 408.49 |
Formula | C24H28N2O4 |
CAS No. | 136152-64-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(R)-(+)-Dimethindene maleate 136152-64-2 inhibitor inhibit