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(+)-Fluprostenol

Name: (+)-Fluprostenol
Brand: TargetMol
SKU: T21224
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21224Cas No. 54276-17-4

Alias Travoprost acid, Fluprostenol, (+)-, AL-5848

(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).

(+)-Fluprostenol

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Purity: 97.35%

Catalog No. T21224Alias Travoprost acid, Fluprostenol, (+)-, AL-5848Cas No. 54276-17-4

(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$77	-	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$313	-	In Stock
25 mg	$578	-	In Stock
50 mg	$833	-	In Stock
100 mg	$1,150	-	In Stock
200 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$196	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.35%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1).
In vivo	(+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats[3].
Synonyms	Travoprost acid, Fluprostenol, (+)-, AL-5848

Chemical Properties

Molecular Weight	458.47
Formula	C₂₃H₂₉F₃O₆
Cas No.	54276-17-4
Smiles	O[C@@H](COc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Relative Density.	1.335 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 325 mg/mL (708.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8 mg/mL (17.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1812 mL	10.9058 mL	21.8117 mL	109.0584 mL
5 mM	0.4362 mL	2.1812 mL	4.3623 mL	21.8117 mL
10 mM	0.2181 mL	1.0906 mL	2.1812 mL	10.9058 mL
20 mM	0.1091 mL	0.5453 mL	1.0906 mL	5.4529 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1812 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc