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(+)-Carbovir triphosphate

Catalog No. T23574 CAS 144606-93-9

Synonyms: LCBVTP, L CBVTP, L-CBVTP

(+)-Carbovir triphosphate is an active metabolite of Abacavir. It was used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase.

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(+)-Carbovir triphosphate Chemical Structure

(+)-Carbovir triphosphate, CAS 144606-93-9

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Biological Description

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Description

(+)-Carbovir triphosphate is an active metabolite of Abacavir. It was used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase.

Synonyms	LCBVTP, L CBVTP, L-CBVTP
Molecular Weight	487.19
Formula	C11H16N5O11P3
CAS No.	144606-93-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Alvarez A, Rios-Navarro C, Blanch-Ruiz MA, Collado-Diaz V, Andujar I, Martinez-Cuesta MA, Orden S, Esplugues JV. Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis. Antiviral Res. 2017 May;141:179-185. doi: 10.1016/j.antiviral.2017.03.001. Epub 2017 Mar 2. PubMed PMID: 28263802. 2. Falcinelli E, Francisci D, Belfiori B, Petito E, Guglielmini G, Malincarne L, Mezzasoma A, Sebastiano M, Conti V, Giannini S, Bonora S, Baldelli F, Gresele P. In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013 Aug;110(2):349-57. doi: 10.1160/TH12-07-0504. Epub 2013 May 23. PubMed PMID: 23703656. 3. Jackson A, Moyle G, Dickinson L, Back D, Khoo S, Taylor J, Gedela K, Abongomera G, Gazzard B, Boffito M. Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects. Antivir Ther. 2012;17(1):19-24. doi: 10.3851/IMP1910. PubMed PMID: 22267465; PubMed Central PMCID: PMC3736319. 4. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28;25(18):2243-8. doi: 10.1097/QAD.0b013e32834d3cc3. PubMed PMID: 21941165; PubMed Central PMCID: PMC3272328.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(+)-Carbovir triphosphate 144606-93-9 LCBVTP Carbovir Triphosphate (+) Carbovir triphosphate L CBVTP (+)Carbovir triphosphate L-CBVTP Carbovir inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.