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NF-κB Signaling Compound Library

Catalog No. L3800

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory proteinIκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzymeIκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results inubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by theproteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such ascoactivatorsandRNA polymerase, which transcribe downstream DNA into mRNA. A large array of genesinvolved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity.

NF-κB Signaling Compound Library from TargetMol, a unique collection of 173 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

Pack Size Price
100 μL * 10 mM (in DMSO) USD 3114.00
250 μL * 10 mM (in DMSO) USD 5536.00
1 mg USD 5536.00

Product Description

  • A unique collection of 173 compounds targeting NF-κB signaling for high throughput screening and high content screening;
  • Effective tool for research in NF-κB signaling and related drug screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

The compound library can be highly customized. You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement. Please check our Compound Library Instructions for more information.

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice; Stable for One year as powder, 6 months at - 20 ° C in DMSO or 12months at -80 ° C in DMSO

Library Composition

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