Compound Libraries NF-κB Signaling Compound Library

NF-κB Signaling Compound Library

Catalog No. L3800
  Library Compound List   Excel SDF

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results in ubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by the proteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such as coactivators and RNA polymerase, which transcribe downstream DNA into mRNA. A large array of genes involved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity.

NF-κB Signaling Compound Library from TargetMol, a unique collection of 173 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 3114.00
250 μL * 10 mM (in DMSO) 5536.00
1 mg 5536.00
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Product Description

  • A unique collection of 173 compounds targeting NF-κB signaling for high throughput screening and high content screening;
  • Effective tool for research in NF-κB signaling and related drug screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

HDAC (47)
NF-κB (39)
PPAR (20)
IκB/IKK (17)
NOD (10)
TNF (9)
COX (8)
P450 (7)
AChR (6)
IL Receptor (5)
PDE (5)
p53 (3)
Lipoxygenase (3)
MMP (3)
EGFR (3)
DNA/RNA Synthesis (2)
GABA Receptor (2)
MPO (2)
Nrf2 (2)
Sirtuin (2)
Retinoid Receptor (2)
ROS (1)
Serine Protease (1)
Sodium Channel (1)
STAT (1)
PKA (1)
Potassium Channel (1)
TRP/TRPV Channel (1)
Wnt/beta-catenin (1)
NPC1L1 (1)
p38 MAPK (1)
HER (1)
LTR (1)
MALT (1)
MAPK (1)
GluR (1)
GSK-3 (1)
E1/E2/E3 Enzyme (1)
Epigenetic Reader Domain (1)
ERK (1)
Estrogen/progestogen Receptor (1)
FGFR (1)
Free radical scavengers (1)
Adenosine Receptor (1)
Adrenergic Receptor (1)
Akt (1)
Antiviral (1)
Apoptosis inducer (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
BACE (1)
CDK (1)
cell cycle arrest (1)
CFTR (1)