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Histone Modification Research Compound Library

Catalog No. L3500

Library Compound List Excel SDF

A histone modification is a covalent post-translational enzymatic modification to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. Histone modification impacts gene expression by altering chromatin structure or recruiting histone modifiers. Therefore, histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Thus, quantitative detection of various histone modifications would provide useful information for a better understanding of epigenetic regulation of cellular processes and the development of histone modifying enzyme-targeted drugs.

The TargetMol’s Histone Modification Research Compound Library, a unique collection of 152 histone modification related compounds, can be used for research in histone modification and related drug screening.

Pack Size	Price/USD
100 μL * 10 mM (in DMSO)	2432.00
250 μL * 10 mM (in DMSO)	4408.00
1 mg	4408.00

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Product Description

A unique collection of 152 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging and Storage

Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
Shipped with blue ice.

Supporting Files

Library Handling Instructions (927 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

HDAC (47)

Epigenetic Reader Domain (33)

Histone Methyltransferase (32)

Sirtuin (17)

Histone Demethylase (11)

JAK (4)

PDE (3)

Histamine Receptor (3)

FLT (2)

AChR (2)

c-RET (2)

DNA-PK (2)

EGFR (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (1)

Adenosine Receptor (1)

Bcr-Abl (1)

COX (1)

GABA Receptor (1)

HER (1)

5-HT Receptor (1)

IκB/IKK (1)

PI3K (1)

PKA (1)

PLK (1)

RAAS (1)

Sigma receptor (1)

Lipoxygenase (1)

Mdm2 (1)

mTOR (1)

NADPH (1)

NF-κB (1)

p53 (1)

TNF (1)

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.