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Compound Libraries TGF-beta/Smad Compound Library

TGF-beta/Smad Compound Library

Catalog No. L4100
  Library Compound List   Excel SDF

Members of the transforming growth factor-β (TGF-β) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) expressed in mammalian tissues. TGF-β isoforms signal through three surface receptors, known as the TGF-β type I, type II, and type III receptors (TβRI, TβRII, and TβRIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-β and receptors transduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes.

TGF-beta/Smad Compound Library from TargetMol, a unique collection of 116 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 1920.00
250 μL * 10 mM (in DMSO) 3211.00
1 mg 3211.00
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Product Description

  • A unique collection of 116 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L4100)

Library Composition

TGF-beta/Smad (25)
Bcr-Abl (21)
PKC (18)
ALK (15)
ROCK (14)
Src (10)
PKA (6)
PDGFR (5)
c-Kit (5)
Akt (4)
Raf (4)
S6 Kinase (3)
mTOR (3)
FGFR (3)
JAK (3)
Aurora Kinase (3)
AMPK (2)
EGFR (2)
Casein Kinase (2)
Ephrin Receptor (2)
ERK (2)
FLT (2)
MEK (2)
Ras (2)
Rho (2)
VEGFR (2)
Topoisomerase (2)
STAT (2)
Tie-2 (1)
TNF (1)
Trk receptor (1)
Potassium Channel (1)
PPAR (1)
Serine/threonin kinase (1)
SGK (1)
S1P Receptor (1)
MLK (1)
PI3K (1)
p38 MAPK (1)
GRK (1)
GTPase (1)
Hck (1)
HER (1)
IGF-1R (1)
MAPK (1)
Caspase (1)
CaMK (1)
Carbonic Anhydrase (1)
Endogenous Metabolite (1)
c-RET (1)
DNA/RNA Synthesis (1)
Apoptosis (1)
Apoptosis inducer (1)
Autophagy (1)
5-HT Receptor (1)
AChR (1)