Compound Libraries Histone Modification Research Compound Library

Histone Modification Research Compound Library

Catalog No. L3500
  Library Compound List   Excel SDF

A histone modification is a covalent post-translational enzymatic modification to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. Histone modification impacts gene expression by altering chromatin structure or recruiting histone modifiers. Therefore, histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Thus, quantitative detection of various histone modifications would provide useful information for a better understanding of epigenetic regulation of cellular processes and the development of histone modifying enzyme-targeted drugs.

The TargetMol’s Histone Modification Research Compound Library, a unique collection of 194 histone modification related compounds, can be used for research in histone modification and related drug screening.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 3104.00
250 μL * 10 mM (in DMSO) 5626.00
1 mg 5626.00
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Product Description

  • A unique collection of 194 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
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Library Composition

Histone Methyltransferase (55)
HDAC (50)
Epigenetic Reader Domain (33)
Histone Demethylase (23)
Sirtuin (20)
Histone Acetyltransferase (6)
Histamine Receptor (5)
JAK (4)
PDE (3)
PI3K (2)
MAO (2)
FLT (2)
AChR (2)
c-RET (2)
DNA Methyltransferase (1)
DNA/RNA Synthesis (1)
DNA-PK (1)
EGFR (1)
Adenosine Receptor (1)
AMPK (1)
Autophagy (1)
BCL (1)
Bcr-Abl (1)
COX (1)
GABA Receptor (1)
Glucagon Receptor (1)
Fatty Acid Synthase (1)
Histone Acetylation (1)
HER (1)
Mdm2 (1)
Mitochondrial Metabolism (1)
MMP (1)
mTOR (1)
NF-κB (1)
5-HT Receptor (1)
IκB/IKK (1)
PKA (1)
PLK (1)
RAAS (1)
Sigma receptor (1)
Lipoxygenase (1)
p53 (1)
TNF (1)