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L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $333 | In Stock | |
5 mg | $790 | In Stock | |
10 mg | $1,120 | In Stock | |
25 mg | $1,670 | In Stock | |
50 mg | $2,180 | In Stock |
Description | L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol. |
Targets&IC50 | AT1 receptor:28 nM (Ki) |
In vitro | METHODS: To determine the characteristics of the non-peptide angiotensin AT1 ligand L162389, a series of affinity assay studies were conducted. RESULTS: L162389 also stimulated phosphatidylinositol turnover, although only a minor fraction of the angiotensin response, acting as an angiotensin antagonist with an IC50 of 105 nM [1]. |
Alias | L-162389, L 162389 |
Molecular Weight | 562.72 |
Formula | C31H38N4O4S |
Cas No. | 169281-53-2 |
Smiles | O=C(OCCCC)NS(=O)(=O)C=1C=CC(=CC1C2=CC=C(C=C2)CN3C4=NC(=CC(=C4N=C3CC)C)C)CCC |
Relative Density. | 1.21 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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