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KI-7

😃Good
Catalog No. T9238Cas No. 1489263-00-4

KI-7 is an adenosine A2B receptor positive allosteric modulator.

KI-7

KI-7

😃Good
Purity: 98.33%
Catalog No. T9238Cas No. 1489263-00-4
KI-7 is an adenosine A2B receptor positive allosteric modulator.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$32In StockIn Stock
5 mg$53In StockIn Stock
10 mg$92In StockIn Stock
25 mg$191In StockIn Stock
50 mg$293In StockIn Stock
100 mg$443In StockIn Stock
200 mg$623-In Stock
1 mL x 10 mM (in DMSO)$59In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.33%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
KI-7 is an adenosine A2B receptor positive allosteric modulator.
In vitro
KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].
Chemical Properties
Molecular Weight354.4
FormulaC23H18N2O2
Cas No.1489263-00-4
SmilesO=C(Nc1ccccc1)C(=O)c1cn(Cc2ccccc2)c2ccccc12
Relative Density.1.18 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 240 mg/mL (677.2 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (9.31 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8217 mL14.1084 mL28.2167 mL141.0835 mL
5 mM0.5643 mL2.8217 mL5.6433 mL28.2167 mL
10 mM0.2822 mL1.4108 mL2.8217 mL14.1084 mL
20 mM0.1411 mL0.7054 mL1.4108 mL7.0542 mL
50 mM0.0564 mL0.2822 mL0.5643 mL2.8217 mL
100 mM0.0282 mL0.1411 mL0.2822 mL1.4108 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Runx2potentiateP1 receptorOsterixorthostericMSCKI-7KI7KI 7InhibitorinhibitcAMPallostericAdenosineReceptorAdenosine ReceptoraccumulationA2B
Related Tags: buy KI-7 | purchase KI-7 | KI-7 cost | order KI-7 | KI-7 chemical structure | KI-7 in vitro | KI-7 formula | KI-7 molecular weight
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