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Bongkrekic acid

Name: Bongkrekic acid
Brand: TargetMol
SKU: T36067
Rating: 4.5 (1 reviews)

(Synonyms: Bongkrek Acid) Copy Product Info

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Synonyms: Bongkrek Acid

Catalog No. T36067 Copy Product Info

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Bongkrekic acid (ammonium salt) is a natural product, a mitochondrial adenine nucleotide translocase (ANT) inhibitor that induces neutrophil extracellular trap formation through signaling pathways such as p38 and ERK, and is used for research on mitochondrial function and immune response.

Cas No. 11076-19-0

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$1,790	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Bongkrekic acid (ammonium salt) is a natural product, a mitochondrial adenine nucleotide translocase (ANT) inhibitor that induces neutrophil extracellular trap formation through signaling pathways such as p38 and ERK, and is used for research on mitochondrial function and immune response.
Targets & IC50	MDA-MB-231 cells:34.14 μM (EC50), LTED:2.58 μM (EC50), MCF-7 cells:> 50 μM (EC50)
In vitro	Methods: Rat liver mitochondria and bovine heart submitochondrial particles were used, and [³H]ADP uptake was measured. Bongkrekic acid was incubated at concentrations of 1–10 μM for 15–20 seconds. Results: At pH 6.0, 1–5 μM Bongkrekic acid significantly inhibited ADP uptake (inhibition rate >80%); at pH 7.4, 5–10 μM showed approximately 30% inhibition, confirming its pH-dependent inhibition of the ADP/ATP carrier.[1] Methods: HepG2 cells were used, and oxygen consumption rate (OCR) was measured by Seahorse extracellular flux analyzer. Bongkrekic acid concentration was 20 μM, with 1-hour pre-incubation. Results: Bongkrekic acid alone significantly inhibited OCR; addition before Oligomycin blocked its induced proton uncoupling, but addition after uncoupling occurred had no reversing effect.[2]
In vivo	Methods: Zebrafish embryos were exposed to Bongkrekic acid (0.01, 0.05, 0.1, 1 mg/L, in water) at 4 hours post-fertilization for 96 hours to assess developmental toxicity. Results: Mortality rates reached 79% in the 0.1 mg/L group and 100% in the 1 mg/L group; exposure to ≥0.05 mg/L resulted in decreased cardiac function and neurobehavioral abnormalities; exposure to ≥0.1 mg/L caused morphological malformations, liver damage, acidosis, and ionoregulatory disorders. [3]
Synonyms	Bongkrek Acid

Chemical Properties

Molecular Weight	486.60
Formula	C₂₈H₃₈O₇
Cas No.	11076-19-0
Smiles	C(\C=C\[C@H](C/C=C/CC/C=C/C=C\C[C@H](/C(=C\C=C(\C(O)=O)/C)/C)OC)C)(/CC(O)=O)=C\C(O)=O

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (164.41 mM), Sonication is recommended.

H2O: 1 mg/mL (2.06 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0551 mL	10.2754 mL	20.5508 mL	102.7538 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4110 mL	2.0551 mL	4.1102 mL	20.5508 mL
10 mM	0.2055 mL	1.0275 mL	2.0551 mL	10.2754 mL
20 mM	0.1028 mL	0.5138 mL	1.0275 mL	5.1377 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0551 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0275 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

PAD4p38MAPKp38 MAPKp38P2XReceptorP2X1P2X ReceptorERKBongkrekic acid

Related Tags: Bongkrekic acid chemical structure | Bongkrekic acid in vivo | Bongkrekic acid in vitro | Bongkrekic acid formula | Bongkrekic acid molecular weight